I have a around 120,000,000 generations so far, genetic, random, all sorts of building blocks etc...no matter the config, P&L by day of the week almost always shows Tuesday as very significantly less than any other day which are relatively similar. P&L on a Tuesday is always almost zero or negative, with all other days pretty much the same.
My only conditions are trading between 06:06 and 18:06 only. Everything is EURUSD H1 or M30 using 5 years of data, tick level and M1.